The Anti Narcotics Force is an attached Department of Ministry of Narcotics Control. ANF is the principal agency for combating supply and demand reduction of illicit narcotic drugs that enter Pakistan mainly through the long porous border with Afghanistan. These drugs are then smuggled out of Pakistan through the Pakistan-Iran border, Makran Coast, Indian ocean and by air. The national strategy on drug interdiction envisages active and effective cooperation from other law enforcement agencies as the ANF is thinly spread due to its inadequate numerical strength. The other law enforcement agencies are the provincial Excise & Taxation Department, Police Department, Pakistan Customs, Frontier Corps in the provinces of Baluchistan and Khyber Pakhtunkhwa, Pakistan Rangers in Sindh and Punjab, the Pakistan Coast Guards and the Maritime Security Agency. The ANF has its Headquarter at Rawalpindi with five Regional Directorates at Rawalpindi, Lahore, Karachi, Peshawar and Quetta.

In addition, it has 28 Police Stations in the country. Six Special Courts for Control of Narcotic Substances (CNS) have been set up to try the cases of persons arrested on the charge of drug trafficking.